Appendix P specifies physical and biological containment conditions and practices suitable to the greenhouse conduct of experiments involving recombinant or synthetic nucleic acid molecule-containing plants, plant-associated microorganisms, and small animals.  All provisions of the NIH Guidelines apply to plant research activities with the following modifications: Appendix P shall supersede Appendix G (Physical Containment) when the…

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This Guide was originally published in 2001 as A Practical Guide to Containment: Greenhouse Research with Transgenic Plants and Microbes and primarily addressed containment of plants and plant-associated organisms containing recombinant DNA (rDNA). Researchers, facility managers, and regulators have subsequently encouraged the authors to expand this Guide beyond containment of solely transgenic organisms. Therefore, the…

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